REACH of Louisville works closely with the Kentucky MHSA Division's Substance Abuse Prevention Partnership in ongoing efforts to improve planning and evaluation efforts that strengthen substance abuse prevention activities. REACH evaluates and contributes to planning processes for a range of prevention programs, campaigns, and initiatives that include both single-strategy and multi-strategy approaches. Through the Partnership REACH has developed data resources to facilitate needs assessment, planning, and evaluation activities, at both the state and community levels. REACH also provides the Partnership with technical assistance, training, and grant writing expertise.

The priority goals for Kentucky's Substance Abuse Prevention Partnership include:
• Increasing rates of abstinence from substances, especially for high-risk and underage populations;
• Delaying the age of onset of substance use to improve likelihood of responsible use for legal substances (e.g., alcohol, tobacco);
• Reducing levels of heavy use and abuse within high-risk populations; and,
• Reducing the overall number of young people and adults that are using tobacco products, engaging in heavy drinking, and using illicit drugs.

Through the Substance Abuse Prevention Partnership REACH has contributed to programs including:
- School-based education programs such as Lifeskills and Project Alert;
- The Prime for Life alcohol and drug prevention curriculum for adults;
- Local ASAP and Champions for a Drug Free Kentucky groups that help identify community-level needs and resources; 
- The SYNAR tobacco sales to minors survey; and,